About Us

About Project ENHANCE

This study will focus on various aspects of the lives and health of children from birth to adulthood with CF. ENHANCE will take place over a five-year period initially with a hope of further long-term extension into the future.

Huge progress has been made in managing cystic fibrosis in children over the last number of decades. A lot of what we understand about CF in childhood comes from research prior to some of the more dramatic improvements in the care of CF in children over the last 10 years. It’s going to be really important for us in the future to ensure that we really understand the evolution of symptoms and signs of disease in CF in this new era. It’s going to be very important for us to know whether outcomes in some children are better than in others and whether some previously seen aspects of disease can be avoided. We want to understand the differences between children without CF and children with CF and understand why some children with CF do better than others.

ENHANCE is a real-world study examining clinical outcomes of people with CF (PwCF) in this new CF care era. This study will involve children with CF across 13 paediatric CF centres in Ireland and the UK. We will be examining a wide range of well-established tests in the people participating in the study, as well as some newer, more sensitive tests looking at how the health and quality of life in people with CF changes over time.

Project ENHANCE – Hospital Network